OFD1 and cancer: To determine whether the disruption of OFD1/F-actin-induced cell cycle arrest is a specific phenotype of hTERT-RPE1 cells or a general phenotype, we tested responses upon OFD1 loss or F-actin dynamics inhibition in several non-transformed cells, such as hTERT-BJ1 and IMR-90, and in multiple types of cancer cells.