OFD1 and cancer: Our previous studies found that autophagy selectively degraded OFD1 localized at centriolar satellites to promote ciliogenesis upon serum deprivation and depletion of OFD1 initiates ciliogenesis in MEFs and non-ciliated MCF7 cancer cells16, while aberrant accumulation of OFD1 attenuates cilia formation in multiple cells via unknown mechanisms16,18.