Our research shows that, in epilepsy, seizure-induced glutamate release activates a prostaglandin-dependent signaling pathway leading to Abcb1 and Abcg2 upregulation at the blood-brain barrier (Bauer et al., 2008b; Pekcec et al., 2009; Zibell et al., 2009; Hartz et al., 2017). This evidence concerns the gene ABCG2 and epilepsy.