Indeed, mice with null deletions of the gene encoding CaMKIIα (CAMK2A KO; Chen et al., 1994), as well as KI mice lacking the T286 autophosphorylation site on CaMKIIα required for its activation (Easton et al., 2011; Gustin et al., 2011), exhibit reduced signs of anxiety-like behavior (Chen et al., 1994) and infusion of the CaMKII inhibitor atCN21 peptide reduces elevated signs of a negative affective state in rats with global cerebral ischemia (Ahmed et al., 2017). This evidence concerns the gene CAMK2A and Anxiety.