However, GRM5R/R mice exhibited a longer latency to first contact the novel object (Genotype effect: F(1,33) = 4.15, p = 0.03; Sex effect and interaction, ps > 0.58; Fig. 4C’’), and made fewer contacts with the novel object (Genotype effect: F(1,33) = 4.28, p = 0.03; Sex effect and interaction, ps > 0.12), indicating that absolute disruption of mGlu5-Homer binding increases anxiety-like behavior in this assay. Here, GRM5 is linked to Anxiety.