As summarized in Table 3, the spontaneous behavior of phospho-mutants incapable of actively-dependent dissociation of Homer2 scaffolds deviated little from their WT littermates, with Homer2AA/AA mutants exhibiting WT-levels of acoustic startle, prepulse inhibition of acoustic startle, spatial learning, memory and reversal learning in a Morris water maze task, anxiety-like behavior in novel object reactivity, marble-burying and forced swim tests, as well as spontaneous, cocaine-induced and cocaine-conditioned motor activity. This evidence concerns the gene HOMER2 and Anxiety.