HOMER2 and early-onset autosomal dominant Alzheimer disease: In this regard, Homer2 interactions with drebrin are particularly intriguing as this F-actin binding protein is central to memory-related hippocampal synaptic plasticity (Jung et al., 2015), is downregulated in postmortem brains of individuals with Alzheimer’s disease (Rao et al., 2011; Counts et al., 2012), and mimicking drebrin down-regulation within hippocampus accelerates cognitive impairment in a genetic mouse model of Alzheimer’s disease (Y. Liu et al., 2017).