LAMB2 and sarcoma: Biliary organoids are increasingly used to model biliary diseases.1,2,4 Organoids are embedded into BME/Matrigel matrix, a complex laminin-rich basement membrane matrix extracted from the Engelbreth-Holm Swarm mouse sarcoma that provides the isolated stem/progenitor cells, the necessary support to self-assemble into 3D structures and differentiate.35 The biological complexity and physical limitations of these matrices, however, represent a challenge for many experimental applications.