CD163 and primary biliary cholangitis: This proinflammatory milieu is associated with subsequent damage to BECs and destruction of bile ducts accompanied by bile leaking into the liver parenchyma causing damage to hepatocytes with subsequent biliary inflammation and portal fibrosis.2,6 In line with this, we observed an association between sCD163 and TNF-α in the newly diagnosed PBC patients before UDCA treatment.