Moreover, a subset of these proteins have been previously linked to AD, including DNAJA1 and BAG2, which promote clearance of misfolded tau aggregates in vitro [72,83,84], HSPA8, which binds tau in vitro upon pharmacologic destabilization of microtubules [63], and HSP90 complex, which interacts with tau oligomers as well as monomer [85]. This evidence concerns the gene BAG2 and Alzheimer disease.