TNF and Cowden disease: Thus, this result opens a new venue for the further analysis of miR-146b-5p as a potential biomarker of cure in CD since the restored level of this miRNA occurred in parallel with parasite clearance after treatment and downregulation of inflammatory mediators, such as TNF/TNFR1 and NO/iNOS pathways, involved in CCC pathogenesis, as previously shown [25,26].