Compared to LRRK2 WT, the LRRK2 R1398H mutation significantly reduced the production of ROS by RAW264.7 cells in response to live M. leprae infection (P < 0.001 at 1-2h post-infection [p.i.], P < 0.01 at 4-6h p.i.)while the N551K variant had no significant effect (Fig 2B). This evidence concerns the gene LRRK2 and infection.