In a mouse model of colitis induced by dextran sodium sulfate, LRRK2 lies downstream of the β-glucan receptor Dectin-1 and overexpression of LRRK2 leads to the activation of the NF-κB components, TAK1 complex and TRAF6, and the enhancement of pro-inflammatory cytokine secretion [65]. This evidence concerns the gene CLEC7A and colitis.