Sleep debt, which occurs through insomnia and short sleep duration, may result in glucose intolerance, decreased thyrotropin secretion, increased cortisol concentration, increased sympathetic nervous activity [38], and elevated C-reactive protein (CRP) levels [39], which are pathophysiological in the development of hypertension [7], and CVD events [40, 41]. The gene discussed is CRP; the disease is insomnia measurement.