BRCA1 and cancer: Of the 187 women with P/LP variants in BRCA1/2, 79 (42.2%) had a personal history of breast cancer with the median age at diagnosis of this cancer of 42 (range 24–81) and 8 (4.3%) had a personal history of ovarian cancer with the mean age at diagnosis of this cancer of 50.1 (standard deviation: 12.4).