In patients carrying pathogenic variants, the BRCA1/2 genes show incomplete penetrance and the cumulative risk at the age of 80 years is up to 72% for breast cancer in BRCA1 P/LP variants carriers and up to 69% in BRCA2 P/LP variants carriers (Kuchenbaecker et al. 2017). This evidence concerns the gene BRCA1 and breast carcinoma.