It can also reportedly downregulate the expression of osteoclastogenesis-related genes while activating mitogen-activated protein kinase (MAPK) signaling and thereby preventing osteoporosis (24, 25), in addition to inducing the AMP-activated protein kinase (AMPK) activation and thereby enhancing angiogenic activity in vitro and in vivo (26). This evidence concerns the gene WNK2 and osteoporosis.