Our data showed that G9a promoted the expression of Notch signaling, and further demonstrated that G9a‐mediated epigenetic silencing of F‐box and WD repeat domain containing 7 (Fbxw7), a known Notch suppressor, elevated the expression of Notch1, which influenced the expressions of stem cell markers and immune‐associated molecules in GBM progression. This evidence concerns the gene NOTCH1 and glioblastoma.