Although all eight parameters for TNM stage, immune, CSCs, and TB, including TNM stage, CD8+ T cells, CD133+ CSCs, TB, CD8+ T cell/CD133+ CSC, CD8+ T cell/TB, TB-adjacent CD8+ T cell, and CD133+ CSC-adjacent CD8+ T cell indices had independent prognostic significance, the complex interplay involved in tumor progression prevented any one of these factors from providing an accurate prediction of survival in patients with PDAC. Here, CD8A is linked to tuberculosis.