In the hAβPP-695/Wtβ-Lonγ AD mice, CTSB KO reduced pGlu-Aβ3 - 40 by 65%, reduced pGlu-Aβ3 - 42 by 90%, also reduced pGlu-Aβ amyloid plaque by 46% in brain [10]. This evidence concerns the gene CTSB and Alzheimer disease.