Significantly, CTSB KO in the hAβPP-695/Wtβ-Lonγ AD mice results in substantial improvement in memory deficits to nearly normal values, reduced brain levels of Aβ peptides of Aβ40, Aβ42, pGlu-Aβ3 - 40, pGlu-Aβ3 - 42, and reduced amyloid plaque load [7, 10]. This evidence concerns the gene CTSB and Alzheimer disease.