APP and Alzheimer disease: To provide the field with an understanding of these different hAβPP models, detailed analysis of these variant hAβPP models is explained in the next section “AD models expressing variant human AβPP isoforms.” Then, evaluations are provided for CTSB KO in Wt β-secretase site hAβPP models representing the major sporadic AD population [18], and CTSB KO in Swe mutant β-secretase site hAβPP models which represent a minor portion of AD patients in one family [19, 20].