PTBP1 and head and neck squamous cell carcinoma: Here, by combining exploration of The Cancer Genome Atlas (TCGA) and GTEX data, RNA/protein biochemistry, and reverse genetics experiments, we show that higher inclusion of the γ exon is associated with poorer survival of patients with HNSCC and we identify the RBP PTBP1 as a direct inhibitor of the inclusion of the γ exon in HNSCC cell lines.