AKT phosphorylation of the H3K4 demethylase KDM5A (6) and the H3K4 methyltransferase KMT2D (also referred to as MLL2/4; ref. 7) in breast cancer has been shown to modulate promoter H3K4me3 and enhancer H3K4me1, respectively. The gene discussed is KMT2D; the disease is breast cancer.