RNA-seq specifically detected increased expression of genes that positively regulate PI3K/AKT signaling, including phospholipid transport proteins (TMEM30b), receptor tyrosine kinases (ERBB4), and an RNA-binding protein that activates PI3K signaling via blocking expression of the tumor suppressor miRNA let7 (LIN28A; Fig. 3D). This evidence concerns the gene AKT1 and neoplasm.