To investigate the role of Pcsk5 in pancreatic carcinogenesis and to evaluate its utility as a therapeutic target for pancreatic cancer therapy, we employed a commercially available and effective general PCs inhibitor, CMK (decanoyl-Arg-Val-Lys-Arg-chloromethlketone), which has been successfully used to suppress growth of certain cancer types (58, 59, 61, 66, 67) but not yet tested in PDAC. This evidence concerns the gene PCSK5 and pancreatic neoplasm.