NOTCH1 and familial pancreatic carcinoma: We performed independent evaluations of the impacts of Notch1 or Notch4 loss in the context of previously established GEMMs for pancreatic cancer, LSL-KrasG12D;p48-Cre and p16fl/fl;LSL-KrasG12D;p48-Cre GEMMs (5, 22).