To determine whether cotargeting endothelial NRP1 and NRP2 impedes tumor growth in already established tumors, we next performed intervention CMT19T allograft studies in our NRP1flflNRP2flfl.ECKO animals, delaying tamoxifen administrations until 7 days after cell implantation (Fig. 1H). The gene discussed is NRP1; the disease is neoplasm.