For example, by crossing NRP2-floxed (NRP2flfl) mice (35) with mice expressing a tamoxifen-inducible Pdgfb-iCreERT2 promoter (41), we previously showed that endothelial NRP2 (NRP2EC) promotes pathologic angiogenesis to support the progression of primary tumors in a lung-carcinoma model. This evidence concerns the gene NRP2 and lung carcinoma.