In particular, the number of relatively large (3.0 mm ≤ Φ), but not small (1.0 mm ≤ Φ < 3.0 mm), diameter tumors was significantly increased in Apc/Dok1/Dok2 mice compared with that in Apc mice (Supplementary Fig. S1B), indicating that Dok-1/-2 deficiency enhances intestinal tumor growth. Here, APC is linked to intestinal neoplasm.