In addition, aside from a suppression of small tumor (1.0 mm ≤ Φ < 2.0 mm) numbers observed in Apc/Dok3/Cd4/Cd8 mice compared with Apc/Dok3 mice, tumorigenesis in Apc/Dok3 mice was not significantly affected by depletion of any of the tested lymphocyte populations (Fig. 4M). This evidence concerns the gene APC and neoplasm.