Regardless of the mechanism responsible for that effect of the ABO phenotype, considering that P[8]-3 strains are overly dominant, we showed here that in a population with a Western European distribution of the ABO, FUT2 and FUT3 alleles, in absence of vaccination, over one third of children are naturally protected from gastroenteritis of sufficient severity to warrant consulting at the hospital emergency department. The gene discussed is ABO; the disease is gastroenteritis.