Martin and Park published “Follow-up with METTLs in Normal and Leukemia Stem Cells” in 2018 [31], which summarized three independent studies that identified METTL3 and METTL14 as vital regulators of differentiation in acute myelocytic leukemia pathogenesis, elucidating the important regulatory role of METTL3 in the pathogenesis of leukemia and further exploration may help to reveal the epigenetic mechanism in the pathogenesis of leukemia. This evidence concerns the gene METTL3 and leukemia.