NLRC4 and hematoma: To the best of our knowledge, our study, for the first time, found that (1) serum NLRC4 levels, which are statistically significantly elevated after ICH, are correlated independently positively with the intensity of neurological symptoms, hemorrhagic focus volume and extent of peripheral inflammation in ICH patients; (2) serum NLRC4 is an independent predictor of END and 6-month poor prognosis; and (3) when combined with NIHSS scores and hematoma volume, serum NLRC4 is in possession of high prognostic predictive ability.