The GSEA results showed that in both IDH-mutant and IDH-wildtype gliomas, systemic lupus erythematosus, viral myocarditis, cytokine signaling in the immune system, innate immune system, and transmission across chemical synapses were among the top five enriched KEGG and Reactome pathways associated with the DEGs between clusters 1 and 2 (Figures 3A–D). Here, IDH1 is linked to central nervous system cancer.