STAT3 and central nervous system cancer: In addition, the GSVA revealed that epithelial-mesenchymal transition, IL6-JAK-STAT3 signaling, IL2-STAT5 signaling, interferon-gamma response, allograft rejection, and coagulation Hallmark gene sets were expressed at a higher level in cluster 2 gliomas of both IDH subtypes (Figures 3E, F).