IDH1 and central nervous system cancer: However, when the gliomas were split by IDH mutational status, the difference in T cells was not significant in IDH-wildtype gliomas, while the infiltration of naïve B cell and plasma cells was significantly lower in cluster 2 of both IDH subtypes, and M2 macrophages were more abundant in cluster 2 gliomas (Figures 4B, C).