(–)-Epigallocatechin-3-gallate (EGCG), a polyphenol abundant in green tea, can downregulate inducible NO synthase (iNOS) and TNF-α expression, and inhibit neuronal death via direct modulation of microglial activation both in SH-SY5Y and in primary rat mesencephalic cultures employed for studying PD (48). This evidence concerns the gene NOS2 and Parkinson disease.