GSDMD and Parkinson disease: Neuroinflammation is capable of inducing the cell apoptosis and/or pyroptosis pathways such as the nod-like receptor pyrin domain-containing protein 3 (NLRP3)/caspase-1/gasdermin D (GSDMD) (28) and the silent mating type information regulation 2 homolog (SIRT1) (29) pathways in PD and the peroxisome proliferator-activated receptor γ (PPARγ) (30) pathway in MS, which inhibits the NF-κB pathway and stimulates Nrf2 expression to counteract OS.