GRIA1 is a subunit in the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of ionotropic glutamate receptors, which is a primary receptor that mediates excitatory synaptic transmission at glutamatergic synapses in the central nervous system and plays key roles in synaptic plasticity, neuronal development, and neurological diseases (52). This evidence concerns the gene GRIA1 and nervous system disorder.