PDPN and ischemic stroke: In this study, the expression of CLEC-2 and Pdpn increased after ischemia/reperfusion (I/R) injury and anti-Pdpn antibody pretreatment reduced infarct volume and attenuated the neurological deficits with a significant decrease of IL-18 and IL-1β, indicating a possible role of the Pdpn/CLEC-2 axis in the regulation of inflammation in ischemic stroke via modulating NLRP3 inflammasome (45).