FADS2 and colorectal carcinoma: Gene expression analysis of CRC using GEO dataset GSE20931 showed that the expression of ELOVL5, FADS2, HSD17B12, and trans-2,3-enoyl-CoA reductase (TECR), the enzymes involved in PUFA elongation and desaturation, were significantly increased in colon cancer samples compared to the normal tissue.