The influence of genetic variations in genes related to prostanoid synthesis, such as prostaglandin-endoperoxide synthase (PTGS) 1, PTGS2, arachidonate lipoxygenase (ALOX) 12, ALOX5, ALOX15, and 5-lipoxygenase activating protein, has been proposed as a reason for the inconsistent results of dietary VL-PUFAs on CRC risk (Habermann et al. 2013). Here, PTGS2 is linked to colorectal carcinoma.