Gene expression analysis of CRC using GEO dataset GSE20931 showed that the expression of ELOVL5, FADS2, HSD17B12, and trans-2,3-enoyl-CoA reductase (TECR), the enzymes involved in PUFA elongation and desaturation, were significantly increased in colon cancer samples compared to the normal tissue. This evidence concerns the gene HSD17B12 and colorectal carcinoma.