However, Zhang et al. found that under starvation conditions, the expression level of H19 in mouse tissues was significantly increased; in addition, in high-fat diet (High-fat diet, HFD) mice and type II diabetes patients; in the liver tissues of HepG2 cells, the expression of H19 showed an upward trend; in vitro experiments showed that after interfering with the expression of H19 in HepG2 cells, the glucose output of cells decreased [40]. Here, H19 is linked to type 2 diabetes mellitus.