Additionally, mineralocorticoid receptor may also participate in activated MPs-induced fibrosis during acute kidney injury (AKI), because mineralocorticoid receptor antagonist Finerenone providing protection against this development of renal fibrosis (90); SGK1, a commonly known downstream signaling molecule of ROS and mineralocorticoids, has also been linked to antigen presentation as a salt sensor in CD11c+ cells (expressed on dendritic cells or macrophages) (91) which leads to an increase in Epithelial sodium channel (ENaC) in these cells (92). The gene discussed is SGK1; the disease is acute kidney injury.