Interestingly, Sorbs2 encodes an intercalated disc (ICD) protein and homozygous Sorb2 KO mutant manifests arrhythmogenic right ventricular cardiomyopathy (ARVC)-like phenotypes, including enlarged right ventricle and cardiac arrhythmia. This evidence concerns the gene SORBS2 and arrhythmogenic right ventricular cardiomyopathy.