Interestingly, Sorbs2 encodes an intercalated disc (ICD) protein and homozygous Sorb2 KO mutant manifests arrhythmogenic right ventricular cardiomyopathy (ARVC)-like phenotypes, including enlarged right ventricle and cardiac arrhythmia. The gene discussed is SORBS2; the disease is Arrhythmogenic right ventricular dysplasia.