According to an animal model established by Song, using STZ-induced type 1 diabetic mice and HG-cultured rat cardiomyocytes, it was confirmed that Sirtuin 3 (SIRT3) deficiency aggravated hyperglycemia-induced mitochondrial damage, increased ROS accumulation, promoted necrosis, and possibly activated NLRP3 inflammatory. The gene discussed is SIRT3; the disease is Hyperglycemia.