In a study conducted by Mao C, the effect of a GPX4 inhibitor on ferroptosis in tumor cells was reversed by dihydroorotate dehydrogenase (DHODH), and this reversal was more significant in tumor cells with a low expression of GPX4, suggesting that DHODH may be the third mechanism of inhibiting ferroptosis (66). The gene discussed is GPX4; the disease is neoplasm.