Other studies report that increased body mass index (BMI) and plasma concentrations of adipokine (both associated with inflammation) correlated with the ketamine response, in other words, lower baseline adiponectin levels correlated with superior antidepressant response to ketamine (percent change from baseline) at 230 min post-infusion [Montgomery-Åsberg Depression Rating Scale (MADRS): r = 0.25, p = 0.03; Hamilton Depression Rating Scale (HAM-D): r = 0.22, p = 0.051] and at day 1 (MADRS: r = 0.28, p = 0.01; HAM-D: r = 0.34, p = 0.002) (13, 34). This evidence concerns the gene ADIPOQ and major depressive disorder.