On the other hand, one could assume that the IDH1 mutation may affect directly NCF; however, IDH1 mutations result in the production of 2-hydroxyglutarate, which may lead to neurodegeneration and neurological cognitive deficits, as in D-2-hydroxyglutaric aciduria, a neurometabolic disease.30Thus, it is more plausible that the favorable cognitive status in IDH1 mutant gliomas is a result by associated molecular genetic characteristics, which may, in turn, lead to increased associated metabolic changes, less growth velocity, and thus to greater plasticity of the adjacent brain tissue. This evidence concerns the gene IDH1 and central nervous system cancer.