IDH1 and glioma: On the other hand, one could assume that the IDH1 mutation may affect directly NCF; however, IDH1 mutations result in the production of 2-hydroxyglutarate, which may lead to neurodegeneration and neurological cognitive deficits, as in D-2-hydroxyglutaric aciduria, a neurometabolic disease.30Thus, it is more plausible that the favorable cognitive status in IDH1 mutant gliomas is a result by associated molecular genetic characteristics, which may, in turn, lead to increased associated metabolic changes, less growth velocity, and thus to greater plasticity of the adjacent brain tissue.