Executive functions were found impaired in our overall sample, highlighting the well-known notion that a glial tumor can have a negative impact on higher cerebral processing.18,19,24–26 However, when we examined the relationship between IDH1 mutation status and NCF in HGGs, we observed that patients with IDH1 mutant-type tumor exhibited less severe cognitive deficits in comparison to patients harboring IDH1 wild-type one. This evidence concerns the gene IDH1 and glioma.