ESR1 and cancer: Five of these genes are known TCGA drivers (ARID1A, ALPK2, PIK3CA, and RNF111 in MSI tumors and MACF1 in MSS tumors), one has been identified as a gastric cancer driver in non-TCGA studies (MUC16), eight are known drivers for other cancer types in TCGA (ATM, CDC27, CDK12, ESR1, KMT2E, and LRRK2) and non-TCGA studies (SYNE1 and NEB), and three have not been previously identified as drivers (EXO1, RTEL1, and FSIP2).