Icilin and WS-3, which are both TRPM8 agonists, suppressed drug-induced EDs and epileptic seizures (Moriyama et al., 2019, 2021), while a TRPM8 deficit led to more severe drug-induced EDs and epileptic seizures (Moriyama et al., 2021). Here, TRPM8 is linked to Ehlers-Danlos syndrome.