PIK3CA and cancer: Two-hundred and fourteen overlapping targets were closely related to “pathways in cancer (hsa05200), “HIF-1 signaling pathway (hsa04066)”, “PI3K-AKT signaling pathway” (hsa04151), “Th17 cell differentiation” (hsa04659), “calcium signaling pathway” (hsa04020), and “Ras signaling pathway” (hsa04014) (Figure 3D).