Recent studies have found that sinensetin can attenuate interleukin-1β-induced cartilage damage ameliorate osteoarthritis by regulating expression of serpin family A member 3, and possesses strong anticancer activities and a wide range of pharmacological (anti-inflammatory, anti-obesity, anti-dementia, vasorelaxant) activities. Here, SERPINA3 is linked to obesity due to melanocortin 4 receptor deficiency.