MYC and neoplasm: In pancreatic cancer, Diferuloylmethane downregulates the expression of NF-κB, miR-21, c-Myc, Hes-1, Stat-3, COX-2, CD-31, VEGF, Notch gene and upregulates the expression of p21 and p27 genes thereby suppress tumor growth (Bimonte et al., 2016).