KRAS and pancreatic adenocarcinoma: To identify differential gene methylation in PAAD, we first performed a comparative analysis of methylation data from 185 KRAS wild-type PAAD samples and 10 normal samples, and identified a total of 2,630 differentially methylated genes (FDR <0.01, |delta β-values| > 0.1, Figure 1A), within the Gene body region, 758 genes were hypermethylated and 418 genes were demethylated.