CD53 and pancreatic adenocarcinoma: A total of 758 hypermethylated genes and 418 demethylated genes were identified within the Gene body region, which was consistent with the incidence of PAAD hypomethylation reported in previous studies, and hypomethylation was mainly associated with cell cycle cycling, cell differentiation, and cell surface antigen/cell adhesion (Pedersen et al., 2011; Schäfer et al., 2021; Zhu et al., 2021).