Nones et al. (2014) used high-density arrays to capture 167 untreated PAAD sample methylation and compared it with normal tissue adjacent to the cancerous one and identified 3,522 abnormally methylated genes. In addition, partial methylation of CDKN1C promoter CpG islands and reduced expression of protein products are observed when comparing PAAD precursor cells methylation expression to normal pancreatic duct epithelial cells (Sato et al., 2008). The gene discussed is CDKN1C; the disease is pancreatic adenocarcinoma.