Studies have shown that the expression of some genes, such as presenilin-2 (PSEN2), DEAD-box helicase 5 (DDX5), and inositol-trisphosphate 3-kinase B (ITPKB), is dysregulated in patients with AD (Kar et al., 2011; Stygelbout et al., 2014; Lanoiselee et al., 2017). The gene discussed is PSEN2; the disease is Alzheimer disease.