The qRT-PCR results showed that memantine (p < .05) and pre-treatment with Augmentin (p < .01) significantly increased PSEN2 expression in scopolamine-induced AD rats (Figure 6A), while ITPKB expression showed a decreasing trend in the AD rats receiving memantine (p < .05) and pre-treatment with Augmentin (p < .0001) (see Figure 6B). This evidence concerns the gene PSEN2 and Alzheimer disease.