Roseburia is a butyric acid-producing bacteria that degrades dietary fiber xylan in the intestinal tract, and butyric acid secreted by gut microbiota will Promote postprandial insulin secretion (Leth ML et al., 2018), suggesting that CCS and CE may reduce blood sugar of T2DM by influencing intestinal microflora. Here, INS is linked to type 2 diabetes mellitus.