TLR4 and obesity due to melanocortin 4 receptor deficiency: Eubacterium_xylanophilum_group could interfere with the catabolism of Branched-Chain Amino Acid (BCAA) to alleviate high-fat induction the body weight of obese mice (Zhang L et al., 2020); Colidextribacter was proved to be an inosine-producing bacterium, which could change the intestinal microbial structure and improve LPS-induced acute liver injury and inflammation by regulating the TLR4/NF-κB signaling pathway, indicating that CCS, CE has a certain positive effect on preventing liver damage and reducing obesity symptoms (Guo W et al., 2021).