LncRNA HOTAIR induced dependent death of mitochondrial calcium uptake 1 (MIUC1) in ccRCC by regulating Bcl-2 and cytochrome c to affect mitochondrial membrane potential (Henzi and Schwaller, 2015; Ding et al., 2018; Zhang H. et al., 2022). This evidence concerns the gene BCL2 and nonpapillary renal cell carcinoma.