ACAT2 and renal cell carcinoma: Another study indicated that there was a strong correlation between the expression of two lipid metabolism enzymes, hydroxyl-coenzyme A dehydrogenase, alpha subunit (HADHA) and acetyl-coenzyme A acetyltransferase 2 (ACAT2), whose down-regulation gave rise to the poor prognosis in RCC patients (Zhao et al., 2016).