Previous studies have demonstrated that emodin could inhibit RhoA and Rock1 on gene and protein levels, and it can also suppress the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway, resulting in the restrained migratory movement of tumor cells (Huang et al., 2005; Tan et al., 2020). The gene discussed is RAC1; the disease is neoplasm.