Cholesterol loading reduced the expression of SCAP and the translocation of SREBP1 to the nucleolus, as well as the expression of key rate-limiting enzymes (fatty acid synthase (FASN) and acetyl-CoA carboxylase 1 (ACC1)) in de novo fatty acid synthesis, inhibiting hepatocellular carcinoma (HCC) progression in vivo and in vitro (Zhao et al., 2019). This evidence concerns the gene SREBF1 and hepatocellular carcinoma.