Cancer cells are sensitive to sterols, and the expression of cholesterol and fatty acid biosynthesis genes (SREBF1/2, stearoyl-CoA desaturase (SCD), FASN) was inhibited by 25-HC in cancer cells, such as glioma, breast cancer, and prostate cancer cells (Williams et al., 2013). This evidence concerns the gene SREBF1 and prostate carcinoma.