Inhibition of SOAT resulted in ER cholesterol accumulation and decreased cholesterol esterification, thereby inhibiting SREBP1-regulated gene expression, glioblastoma growth, and prostate cancer cell invasion (Yue et al., 2014; Geng et al., 2016; Navarro-Imaz et al., 2019). Here, SREBF1 is linked to glioblastoma.