In liver cancer cells, DHA inhibits SREBP1c at the mRNA and protein levels; however, the inhibition of SREBP1c expression by DHA is related to free fatty acid receptor 4 (FFA4, a G protein-coupled receptor and target of DHA (Hirasawa et al., 2005)), and its inhibitory effect is attenuated by FFA4 knockdown (Kang et al., 2018). The gene discussed is SREBF1; the disease is liver cancer.