Interestingly, in non-tumorigenic MCF10A epithelial cells, YAP activates mTORC1/SREBP1 via serum and glucocorticoid-regulated kinase 1, rather than the AKT-mediated mTORC1/SREBP1 mechanism, which conflicts with the performance of hepatocellular carcinoma (Vaidyanathan et al., 2022). Here, YAP1 is linked to hepatocellular carcinoma.