SOD1 and Myocardial fibrosis: The cardioprotective protective mechanisms involved in our study included cardiomyocyte inflammation, oxidation, apoptosis, myocardial fibrosis, and et al. A meta-analysis of four animal studies (Cheng et al., 2005; Gonzalez-Salazar et al., 2011; Yao and Jiang, 2014; Liu et al., 2017b) showed that curcumin had a significant effect on increasing SOD expression compared with the control group (n = 156, SMD = 4.47, 95% CI (1.17, 7.78), p = 0.008, I2 = 95%) (Figure 6A).