Univariate and multivariate Cox regression analyses of both the EGFR-TKI-treated and ICI-treated cohorts confirmed that sarcopenia was an independent negative factor for OS (EGFR-TKI-treated group, HR: 2.806, 95% CI: 1.304–6.037, p = 0.008; Supplementary Table 3; ICI-treated group, HR: 2.155, 95% CI: 1.107–4.484, p = 0.028; Supplementary Table 4). This evidence concerns the gene EGFR and sarcopenia.