Probiotics-derived bacteriocins, including plantaricin JLA-9, plantaricin W, lactococcin A, and lactococcin MMFII directly interact with CRC-promoting protein COX2 and modulate inflammasome complex NLRP3 and NF-kB pathways to reduce CRC-associated inflammation. The gene discussed is PTGS2; the disease is colorectal carcinoma.