SLC52A2 and colorectal carcinoma: In contrast, the involvement of GPCR41 in SCFA-mediated signaling during CRC development has not been fully clarified, except for one study showing that the overexpression of GPCR41 depressed forskolin-stimulated cyclic AMP (cAMP) formation in response to SCFA treatment, similar to the endogenous function of GPCR41 in regulating Gαi/o activity (264).