Regarding the molecular mechanism of SCFAs in CRC development, it was shown that butyrate acid could suppress the expression of Neuropilin-1 (NRP-1) by inhibiting the activity of specificity protein 1 (Sp1), which eventually leading to the inhibition of angiogenesis and metastasis of colorectal cancer cells (255). The gene discussed is NRP1; the disease is colorectal carcinoma.