FFAR2 and colorectal carcinoma: Mechanistic analysis further revealed that loss of GPCR43 leads to upregulation of cAMP/Protein Kinase A (PKA)/cAMP response element binding protein (CREBP)/histone deacetylase (HDAC) signaling axis, along with upregulated Wnt signaling and the downstream activation of nuclear β-catenin and c-Myc, suggesting the role of G protein-linked epigenetic modification in promoting CRC development (263).