In the assessment of discriminative capacity, the prognosis model exhibited remarkable accuracy (C-index, 0.78; 95% CI, 0.67–0.88) overperforming the 8th edition AJCC staging system (C-index, 0.54; 95% CI, 0.41–0.67) and the individual prognostic parameters (CA19-9 [C-index, 0.65; 95% CI, 0.47–0.82), CEA [C-index, 0.62; 95% CI, 0.46–0.78], tumor size [C-index, 0.60; 95% CI, 0.46–0.74], tumor differentiation [C-index, 0.57; 95% CI, 0.46–0.69] and T stage [C-index, 0.54; 95% CI, 0.41–0.67]) (Supplementary Figure S4A), with a good calibration (Supplementary Figure S4B). This evidence concerns the gene CEACAM5 and neoplasm.