The cytokine storm, with its uncontrolled and robust release of pro-inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-α), is the peak of the detrimental immune hyperactivation seen in COVID-19 (20–22). The gene discussed is TNF; the disease is COVID-19.