The first stage of thyroiditis, thyrocyte breakdown resulting in hyperthyroidism, is marked not only by an uninhibited leak of peripheral thyroid hormones from the damaged gland, but also by a simultaneous release of TG, a glycoprotein stored within the thyroid follicular lumen, crucial for hormonogenesis and considered a biomarker of destructive thyroiditis (29, 33). The gene discussed is TG; the disease is thyroiditis.