TRPC3 channels have been shown to play a role in cardiac fibrosis and fibrosis-associated heart diseases, such as atrial fibrillation (AF) and HF induced by pressure overload (Kiyonaka et al., 2009; Harada et al., 2012; Numaga-Tomita et al., 2017). The gene discussed is TRPC3; the disease is atrial fibrillation.