Another study involving patients with polycystic ovarian syndrome (PCOS) reported that the deletion of exosomal circLDLR in receptor cells enhanced the expression of miR-1294 and inhibited that of CYP19A1, which consequently inhibited estradiol secretion and ultimately resulted in aberrant follicular growth (Huang et al., 2020). This evidence concerns the gene CYP19A1 and polycystic ovary syndrome.